Re: Random Idea I had to get out of my head before I start obsessing over it.
Ahem. Probably the easiest and most efficient way to deal with the making of sprites is designing the views of the character (i.e., front, side, 3q, etc) that will be needed in a vector drawing program, and then just animating them according to what the game needs. You can create the widest array of movements and positions with just the basic layouts for your characters, and you won't be constrained by the resolution of your drawings, because you will be working with vectors. The programs I would recommend the most for this kind of task are Anime Studio or Flash. Also, if you aren't a really good designer to begin with, as to set up the different views of the character from scratch, I'd recommend working with rendered 3d models from the required perspectives, to later trace those renders in your vector application. Of course, once you have animated your characters, you just export the corresponding sequences as pngs.
Just my 2c.
PS: there's a chinese page with TONS of videogame 3d models ripped for download (
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), in case you need to use a popular character for inspiration.
PS2: with this method, you only need to trace one model really; you can add additional clothes, hair styles, etc, just by making new layers, attached to the main body/armature/bone system/whatever you're using. Then you separate the model by body parts and export the sprites for later use... You won't need more than a couple of days to get all the animation you need this way.